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rma [2010/09/29 13:38]
mbleda
rma [2017/05/24 10:36] (current)
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 +====== RMA Normalization ======
  
 +**RMA** ([[http://biostatistics.oxfordjournals.org/cgi/content/abstract/4/2/249|"Robust Multi-Array"]]) background correction is followed by a [[http://bioinformatics.oxfordjournals.org/cgi/content/abstract/19/2/185|"quantile"]] scale transformation to get similar intensity distribution across arrays.
 +
 +Only Perfect Match (**PM**) probes are used in the computation Missmatch (**MM**) probes are discarded and [[http://en.wikipedia.org/wiki/Median_polish|"median polish"]] is used to summarize probe-sets into a unique intensity measuremen. RMA returns normalized data in **log2** scale, as in the original RMA implementation.
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