We have several candidate profiles of mutations because it is clear the kind of mutation we are searching but sometimes we do not have a specific clues.

1. Recessive heritage
2. Dominant heritage (mother is affected).
3. For these region, only chromosome: 3,19
4. Evaluate the same regions, including start and end at the first region: 3:1000-200000,19
5. For this gene: SDC3
6. Description of variants. How many SNVs, INDELs, MNVs, SVs, CNVs?
7. Variants with MAF (Minimum Allelic Frequency) < 0.05 for AFR populations in 1000 Genomes phase 1
8. Variants with MAF (Minimum Allelic Frequency) < 0.05 for AFR populations in 1000 Genomes phase 3
9. Variants with MAF (Minimum Allelic Frequency) < 0.05 for African American population in ESP 6500
10. For sift<0.05 and polyphen >0.95, because it is likely pathogenic

1. Can you apply filters to search “Insuline Resistance” phenotype in recesive heritage?