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RMA Normalization

RMA ("Robust Multi-Array") background correction is followed by a "quantile" scale transformation to get similar intensity distribution across arrays.

Only Perfect Match (PM) probes are used in the computation Missmatch (MM) probes are discarded and "median polish" is used to summarize probe-sets into a unique intensity measuremen. RMA returns normalized data in log2 scale, as in the original RMA implementation.

rma.txt · Last modified: 2017/05/24 10:36 (external edit)
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